ICMR – Central News Hub

ICMR team designs kit to detect Omicron variant in 2 hours

The kit is now being produced on a bulk basis by the West Bengal-based GCC Biotech on a public-private partnership (PPP) model…reports Asian Lite News.

The Indian Council of Medical Research (ICMR) has developed a testing kit which can detect the new Omicron Covid-19 variant within two hours.

The kit has been designed by a team of ICMR scientists from the Regional Medical Research Centre (RMRC) for the Northeast region led by scientist Dr Biswajyoti Borkakoty.

“ICMR-RMRC, Dibrugarh, has designed and developed a hydrolysis probe-based real-time RT-PCR assay for detection of the new Omicron variant (B.1.1.529) SARS-CoV-2 that can detect the new variant within two hours. This is important because as of now a minimum of 36 hours is required for targeted sequencing and 4 to 5 days for whole-genome sequencing to detect the variant,” said Dr Borkakoty.

Generally, it takes three to four days to detect the Omicron variant in infected people.

The kit is now being produced on a bulk basis by the West Bengal-based GCC Biotech on a public-private partnership (PPP) model.

Omicron

With the latest Omicron case detected in Delhi on Saturday, overall tally of persons infected by the variant has climbed to 33 in India.

Delhi reported its second case of Omicron on Saturday after a fully vaccinated individual with a travel history to Zimbabwe and South Africa tested positive.

Maharastra is on top of the list of states which have reported Omicron cases, followed by Delhi, Rajasthan, Gujarat and Karnataka.

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ICMR releases new study on Covaxin doses

The antibody responses of individuals with confirmed pre-vaccination SARS-CoV-2 infection were compared with those individuals without prior evidence of infection…reports Asian Lite News.

A single-dose of Covaxin provides a similar immunity response in previously Covid-infected people as those without previous history of Covid infection with two doses of vaccine, says Indian Council of Medical Research’s latest study.

The ICMR in its recent study has found that the people already infected with Covid-19 while taking a dose of Covaxin have the same or increased antibody response as unaffected people taking two doses of Covaxin.

The pilot study was undertaken to examine SARS-CoV-2 specific antibody responses after day 0 (baseline before vaccination), day 28A2 days post-first dose (month 1) and day 56A2 days post-first dose (month 2) of BBV152 in a group of healthcare professionals as well as frontline workers.

The antibody responses of individuals with confirmed pre-vaccination SARS-CoV-2 infection were compared with those individuals without prior evidence of infection.

The blood specimens were collected from healthcare professionals and frontline workers who received BBV152 vaccine at vaccination centres in Chennai, India, during February to May 2021.

Blood samples were collected before receiving the first dose of BBV152. Prior infection with SARS-CoV-2 was determined by SARS-CoV-2 IgG positivity at baseline. The study was approved by the Ethics Committee of ICMR-NIRT.

Antibody levels were measured at three time points: on the day of vaccination (baseline), at month one following the first dose and at month two following the first dose.

https://www.youtube.com/watch?v=ngCvDWwuEgM

The results were determined via a calibration curve, which is an instrument specifically generated by two-point calibration and a master curve provided via the reagent QR code.

Almost all participants with prior Covid-19 infection except two had detectable antibodies at the time of vaccination. This study offers evidence in support of public health-oriented and immunologically sustained vaccine strategies.

Lokesh Sharma, Scientist and Media Coordinator, ICMR, says, “This is a pilot study. If such findings are confirmed in large population studies, a single dose of BBV152 vaccine may be recommended to previously confirmed Covid patients so that the naA-ve individuals could attain the larger benefit of a limited vaccine supply.”

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